Low-Substituted Hydroxypropyl Cellulose

Low-substituted hydroxypropyl cellulose is widely used in oral solid-dosage forms. It is primarily used as a disintegrant, and as a binder for tablets and granules in wet or dry granulation. It has been used in the preparation of rapidly disintegrating tablets produced by direct compression methods. In addition, lowsubstituted hydroxypropyl cellulose has been used as a binder/ disintegrant included in the powder layering process on spherical cores and to prepare pellets by extrusion/spheronization. A low particle size and high hydroxypropyl content is recommended to produce round spheres and rapid dissolution. There are a number of grades that have different particle sizes and substitution levels. LH-11 has the longest fibrous particles, and H 322 Hydroxypropyl Cellulose, Low-substituted is typically used as an anticapping agent and disintegrant for direct compression. LH-21 is less fibrous and is used as a binder and disintegrant for tablets through the wet-granulation process. LH-31 is a small-particle grade used especially for extrusion to produce granules, as it has a small particle size that is better for passing a screen. LH-B1 is the nonfibrous, high-density grade designed for fluid-bed granulation, and can be used for direct compression and/ or formulations with a high low-substituted hydroxypropyl cellulose loading. Lower substitution grades LH-22 and LH-32 can be used for better disintegration capability, depending on the characteristics of the active ingredients. The typical content of low-substituted hydroxypropyl cellulose in a formulation is approximately 5–50%.

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